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Advanced filters: Author: Timmy Hohnecker Clear advanced filters

  • Neither CDK4/6 inhibitors nor oncolytic adenoviruses show high efficiency as monotherapy in the treatment of cancer. Authors show here that when combined, CDK4/6 inhibitors deplete Retinoblastoma protein levels, which leads to more efficient virus replication and an increase in oncolytic virus-producing cancer cells and thus to efficient anti-tumor response in mouse xenograft sarcoma models.

    • Jana Koch
    • Sebastian J. Schober
    • Per Sonne Holm
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18