The 'somatic growth axis' involving IGF-1 and growth hormone is implicated in longevity. Persistent transcription-blocking DNA damage attenuates growth hormone and IGF-1 receptor expression and precipitates other ageing associated transcriptional changes, as well as inhibiting somatic growth.
- George A. Garinis
- Lieneke M. Uittenboogaard
- Björn Schumacher