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Showing 1–12 of 12 results
Advanced filters: Author: Timothee Lionnet Clear advanced filters

  • What regulates mRNAs transcript localization in the germ granules in Drosophila is unclear. Here Trcek et al.identify that germ plasm proteins are homogeneously distributed in germ granules but once localized, individual mRNAs form homotypic clusters, contributing structure to the germ granules.

    • Tatjana Trcek
    • Markus Grosch
    • Ruth Lehmann
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • RS-FISH is a user-friendly software for accurate spot detection that is applicable to smFISH experiments, spatial transcriptomics, and spatial genomics. The approach enables fast spot detection in even very large volumetric datasets.

    • Ella Bahry
    • Laura Breimann
    • Stephan Preibisch
    ResearchOpen Access
    Nature Methods
    Volume: 19, P: 1563-1567

  • Tumour cells adapt to anticancer drug treatments by a series of cellular state transitions, each inducing distinct gene expression programmes and leading to increased drug resistance.

    • Gustavo S. França
    • Maayan Baron
    • Itai Yanai
    Research
    Nature
    Volume: 631, P: 876-883

  • Single-molecule fluorescence in situ hybridization (smFISH) enables mRNA quantification while preserving spatial information. Trcek et al. describe an smFISH procedure for Drosophila embryos, using wide-field, confocal and structured illumination miscroscopy.

    • Tatjana Trcek
    • Timothée Lionnet
    • Ruth Lehmann
    Protocols
    Nature Protocols
    Volume: 12, P: 1326-1348

  • In this study the authors utilise Hi-C, ATACseq, and RNA-seq data from 12 diagnosis/relapse matched leukemia specimens to reveal 3D genome organization as a critical factor in reshaping the transcriptional output of leukemia cells under the selective pressures of therapy.

    • Sonali Narang
    • Yohana Ghebrechristos
    • William L. Carroll
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Analysis of 3D chromatin architecture in T-ALL identifies differences in intra-TAD interactions and TAD boundary insulation. Inhibition of oncogenic signal transduction or epigenetic regulation can alter specific 3D interactions.

    • Andreas Kloetgen
    • Palaniraja Thandapani
    • Aristotelis Tsirigos
    Research
    Nature Genetics
    Volume: 52, P: 388-400

  • The precise execution of biological processes depends on various different macromolecules, such as proteins, working together in a coordinated manner. The idea is that the mRNA level of essential genes encoding proteins in the same complex or pathway would be more correlated than transcripts of functionally unrelated genes. It turns out that this holds true for induced genes but not for transcripts of constitutive genes encoding essential subunits of multi-protein complexes. These transcripts are not correlated any more than functionally unrelated genes. The coordination of these functional complexes must occur post-transcriptionally, and likely post-translationally.

    • Saumil J Gandhi
    • Daniel Zenklusen
    • Robert H Singer
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 27-34

  • Improved fluorescence in situ hybridization enables smFISH in cleared whole-mount Drosophila brains with confocal microscopy; a custom Bessel beam structured illumination microscope allows single-mRNA detection across the entire brain.

    • Xi Long
    • Jennifer Colonell
    • Timothée Lionnet
    Research
    Nature Methods
    Volume: 14, P: 703-706

  • Photoactivatable derivatives of the bright and photostable Janelia Fluor dyes enable improved multicolor single-particle tracking and facile localization microscopy in cells.

    • Jonathan B Grimm
    • Brian P English
    • Luke D Lavis
    Research
    Nature Methods
    Volume: 13, P: 985-988