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Showing 1–12 of 12 results
Advanced filters: Author: Timothy H. Bestor Clear advanced filters

  • There are two biological properties of genomic methylation patterns that can be regarded as established. First, methylation of 5′-CpG-3′ dinucleotides within promoters represses transcription, often to undetectable levels. Second, in most cases methylation patterns are subject to clonal inheritance. These properties suit methylation patterns for a number of biological roles, although none of the current hypotheses can be regarded as proved or disproved. One hypothesis suggests that the activity of parasitic sequence elements is repressed by selective methylation. Features of invasive sequences that might allow their identification and inactivation are discussed in terms of the genome defense hypothesis. Identification of the cues that direct de novo methylation may reveal the biological role (or roles) of genomic methylation patterns.

    • Timothy H. Bestor
    • Benjamin Tycko
    Comments & Opinion
    Nature Genetics
    Volume: 12, P: 363-367

  • Timothy Bestor and colleagues disrupt the Fbxl10 gene in mice, which leads to dense de novo DNA methylation of promoters that are co-occupied by both FBXL10 and by Polycomb repressive complexes. They conclude that FBXL10 protects Polycomb-bound genes from hypermethylation.

    • Mathieu Boulard
    • John R Edwards
    • Timothy H Bestor
    Research
    Nature Genetics
    Volume: 47, P: 479-485

  • Konrad Hochedlinger and colleagues show that ascorbic acid enhances cellular reprogramming by preventing hypermethylation of the imprinted Dlk1-Dio3 locus. They use this approach to generate adult mice derived entirely from induced pluripotent stem cells obtained through reprogramming of terminally differentiated B cells.

    • Matthias Stadtfeld
    • Effie Apostolou
    • Konrad Hochedlinger
    Research
    Nature Genetics
    Volume: 44, P: 398-405

  • DNMT3L, a regulatory factor related in sequence to DNA methyltransferases, is shown to interact with the N terminus of histone H3 and this interaction is inhibited by methylation at lysine 4. This suggests DNMT3L could respond to states of histone modification to regulate de novo DNA methylation.

    • Steen K. T. Ooi
    • Chen Qiu
    • Timothy H. Bestor
    Research
    Nature
    Volume: 448, P: 714-717

  • Females have two copies of the X chromosome, yet the genes on only one copy are active. Genes on the other copy are turned off by cytosine methylation. For the first time, a link has been found between this methylation process and acetylation of histones —the protein balls around which the DNA in chromosomes is wrapped. A protein called MeCP2, which binds only to methylated DNA sequences, exists in a complex with histone deacetylase, which removes acetyl groups from the histones, causing them to condense and become transcriptionally inactive.

    • Timothy H. Bestor
    News & Views
    Nature
    Volume: 393, P: 311-312

  • Recent publications suggest that certain proteins of the Polycomb group interact with DNA methyltransferases. This may connect the two systems that are known to mediate somatic inheritance of states of gene expression during development.

    • Marc Damelin
    • Steen K T Ooi
    • Timothy H Bestor
    News & Views
    Nature Structural & Molecular Biology
    Volume: 13, P: 100-101

  • Human embryos that develop in the presence of chromosomes solely of paternal origin give rise only to a disorganized mass of placental derivatives known as a complete hydatidiform mole. A new study reports that mutations in NALP7, a gene thought to be involved in inflammatory and apoptotic pathways, occur in human females whose biparental conceptuses can develop as apparent complete moles.

    • Timothy H Bestor
    • Déborah Bourc'his
    News & Views
    Nature Genetics
    Volume: 38, P: 274-276