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Showing 1–8 of 8 results
Advanced filters: Author: Timothy R. Blosser Clear advanced filters

  • Single-nucleus and single-cell RNA sequencing plus spatial profiling with four methods of core biopsies from 60 patients with metastatic breast cancer reveal patient-specific gene expression programs of breast cancer metastases that are maintained across time, site of metastasis and spatial profiling method, with spatial phenotypes correlating with microenvironmental features.

    • Johanna Klughammer
    • Daniel L. Abravanel
    • Nikhil Wagle
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 3236-3249

  • A study integrating single-cell RNA-sequencing and electrophysiology data shows that in mouse, the cellular repertoire of the thalamic reticular nucleus is characterized by a transcriptomic gradient defined at its extremes by mutually exclusive expression of Spp1 and Ecel1, providing insights into the organizational principles underlying the divergent functions of this brain region.

    • Yinqing Li
    • Violeta G. Lopez-Huerta
    • Guoping Feng
    Research
    Nature
    Volume: 583, P: 819-824

  • The authors generated a cell census of mouse nucleus accumbens using single-cell RNA sequencing and multiplexed error-robust FISH. These data suggest that transcriptional and spatial diversity of neuron subtypes underlies nucleus accumbens anatomic and functional heterogeneity.

    • Renchao Chen
    • Timothy R. Blosser
    • Yi Zhang
    Research
    Nature Neuroscience
    Volume: 24, P: 1757-1771

  • The ATP-dependent chromatin assembly factor (ACF) generates regularly spaced nucleosomes, but the mechanism by which ACF mobilizes nucleosomes remains poorly understood. Here, single-molecule FRET is used to monitor the remodelling of individual nucleosomes by ACF in real time; the study reveals previously unknown remodelling intermediates and dynamics, and indicates that ACF is a highly processive and bidirectional nucleosome translocase.

    • Timothy R. Blosser
    • Janet G. Yang
    • Xiaowei Zhuang
    Research
    Nature
    Volume: 462, P: 1022-1027

  • Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.

    • Jeffrey A. Schneider
    • Timothy W. Craven
    • Susan K. Logan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • The imminent release of tissue atlases combining multichannel microscopy with single-cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards to guide data deposition, curation and release. We describe a Minimum Information about Highly Multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and for other microscopy data to highly multiplexed tissue images and traditional histology.

    • Denis Schapiro
    • Clarence Yapp
    • Peter K. Sorger
    Comments & Opinion
    Nature Methods
    Volume: 19, P: 262-267