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Translocation arrest of an intramitochondrial sorting signal next to Tim11 at the inner-membrane import site

Kostas Tokatlidis
Tina Junne
Benjamin S. Glick
Research12 Dec 1996
Nature

Volume: 384, P: 585-588
Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model

Pseudomonas aeruginosa infection of human lower airway organoids reveals that bacterial invasion of goblet cells and triggering of cell death promote breaching of the respiratory epithelium.

A. Leoni Swart
Benoît-Joseph Laventie
Urs Jenal
Research10 Jun 2024
Nature Microbiology

Volume: 9, P: 1725-1737
A common mechanism of Sec61 translocon inhibition by small molecules

Itskanov and Wang et al. determined high-resolution structures of the human Sec61 channel inhibited by several structurally distinct small molecules and revealed the common inhibitor-binding site in Sec61 and molecular interactions in atomic detail.

Samuel Itskanov
Laurie Wang
Eunyong Park
Research11 May 2023
Nature Chemical Biology

Volume: 19, P: 1063-1071

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Translocation arrest of an intramitochondrial sorting signal next to Tim11 at the inner-membrane import site

Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model

A common mechanism of Sec61 translocon inhibition by small molecules

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