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Showing 1–3 of 3 results
Advanced filters: Author: Tineke L. Lenstra Clear advanced filters

  • Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenous gene.

    • Tineke L. Lenstra
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 422

  • Using single-molecule transcription imaging upon perturbations to nucleosome remodelers, the transcription factor and the transcriptional machinery, Brouwer et al. reveal how remodeling of promoter nucleosomes regulates the kinetics of transcription.

    • Ineke Brouwer
    • Emma Kerklingh
    • Tineke L. Lenstra
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 692-702

  • Here the authors show that the regulatory mechanism for transcription of the yeast PHO5 gene operates away from equilibrium, contrary to common assumption about transcriptional regulatory processes. This occurs through the activation domain of the Pho4 activator, which mediates coupling to reservoirs of free energy.

    • Robert Shelansky
    • Sara Abrahamsson
    • Hinrich Boeger
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9