Enantiopure pillar[5]arenes are valued for their roles in host–guest recognition and chiral sensing, but the current synthesis of these compounds via asymmetric catalysis remains challenging. Here, the authors develop an asymmetric extended side-arm Suzuki–Miyaura cross-coupling strategy to construct inherently chiral pillar[5]arenes.
- Ting-Rui Luan
- Che Sun
- Ren-Rong Liu