Nature Search

A histone-centric multi-omics study shows that increased H3K4 methylation sustains triple-negative breast cancer phenotypes

Using a histone focused multi-omics approach, here the authors show that increased H3K4 methylation drives triple-negative breast cancer phenotypes, revealing potential novel therapeutic avenues.

Roberta Noberini
Giulia Robusti
Tiziana Bonaldi
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Epigenetic drug target deconvolution by mass spectrometry–based technologies

Noberini and Bonaldi discuss how mass spectrometry–based technologies aid in identifying the full target spectrum of bioactive molecules.

Roberta Noberini
Tiziana Bonaldi
Reviews03 Oct 2019
Nature Structural & Molecular Biology

Volume: 26, P: 854-857
miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth

The synergism between c-MYC and miR-17-19b plays an important role in lymphoma initiation. In this study, the authors identify a panel of targets co-regulated by miR-17-19b and in MYC-driven lymphoma and unravel the molecular mechanism through which miR-17-19b inhibits MYCtranslation.

Marija Mihailovich
Michael Bremang
Tiziana Bonaldi
ResearchOpen Access10 Nov 2015
Nature Communications

Volume: 6, P: 1-15
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

Histone post-translational modifications are known key regulators of gene expression. Here, the authors characterize histone crotonylation at histone H3 lysine 18 in intestinal epithelia and find that it is a highly dynamic cell cycle regulated mark under the regulation of the HDAC deacetylases.

Rachel Fellows
Jérémy Denizot
Patrick Varga-Weisz
ResearchOpen Access09 Jan 2018
Nature Communications

Volume: 9, P: 1-15
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

Dorothea Greiner
Tiziana Bonaldi
Axel Imhof
Research17 Jul 2005
Nature Chemical Biology

Volume: 1, P: 143-145
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F Fraga
Esteban Ballestar
Manel Esteller
Research13 Mar 2005
Nature Genetics

Volume: 37, P: 391-400
Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML

Luciano Nicosia
Francesca Ludovica Boffo
Tiziana Bonaldi
ResearchOpen Access03 Dec 2021
Oncogene

Volume: 41, P: 878-894
Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases"

Dorothea Greiner
Tiziana Bonaldi
Axel Imhof
Correspondence15 Feb 2013
Nature Chemical Biology

Volume: 9, P: 137
Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry

Michael L Nielsen
Michiel Vermeulen
Matthias Mann
Correspondence01 Jun 2008
Nature Methods

Volume: 5, P: 459-460
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death

The cancer therapeutic cetuximab blocks EGFR signaling on tumor cells. Pozzi et al. now show that this antibody, when combined with chemotherapy, can also kill colorectal cancer cells by triggering immunogenic cell death.

Chiara Pozzi
Alessandro Cuomo
Maria Rescigno
Research02 May 2016
Nature Medicine

Volume: 22, P: 624-631
A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression

Elena Di Nisio
Valerio Licursi
Rodolfo Negri
ResearchOpen Access26 Jan 2023
Cancer Gene Therapy

Volume: 30, P: 822-832
Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation

Stefano Amatori
Giuseppe Persico
Mirco Fanelli
ResearchOpen Access19 Dec 2022
Cancer Gene Therapy

Volume: 30, P: 671-682

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