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Membrane tension and peripheral protein density mediate membrane shape transitions

An ultrafast mechanism of endocytosis was recently discovered, and proposed to be dependent on local reduction in membrane tension. Shi and Baumgart provide experimental support for this hypothesis by quantifying the impact of membrane tension on membrane tubulation by endocytic proteins, such as endophilin A1.

Zheng Shi
Tobias Baumgart
Research08 Jan 2015
Nature Communications

Volume: 6, P: 1-8
Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation

Here the authors show that protein phase separation is a key mechanism in cellular receptor internalization via fast endophilin mediated endocytosis (FEME). Phase separation facilitates multivalent FEME-protein assembly in this clathrin-independent pathway.

Samsuzzoha Mondal
Karthik Narayan
Tobias Baumgart
ResearchOpen Access26 Aug 2022
Nature Communications

Volume: 13, P: 1-20
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension

Tobias Baumgart
Samuel T. Hess
Watt W. Webb
Research23 Oct 2003
Nature

Volume: 425, P: 821-824
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding

Controlled domain formation in block copolymer mixtures or lipid bilayers could lead to more highly ordered assemblies and delivery of drugs. It is now shown that mesoscale domain formation within assembled mixtures of neutral and anionic polymer amphiphiles can be induced by the divalent cations calcium and copper.

David A. Christian
Aiwei Tian
Dennis E. Discher
Research06 Sept 2009
Nature Materials

Volume: 8, P: 843-849
Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception

The vascular stem cell niche regulates the proliferation and differentiation of neural stem cells (NSCs) in the adult subventricular zone. Here the authors identify EGFL7 as a neurovascular regulator of NSCsin vivo; EGFL7-knockout mice show reduced neurogenesis, and exhibit impaired olfactory perception and behaviour.

Frank Bicker
Verica Vasic
Mirko H. H. Schmidt
ResearchOpen Access28 Jun 2017
Nature Communications

Volume: 8, P: 1-16
Coupling between endocytosis and sphingosine kinase 1 recruitment

De Camilli and colleagues reveal that reducing cholesterol or sphingomyelin causes formation of tubular structures resembling early endocytic intermediates at the plasma membrane. These structures recruit sphingosine kinase 1 (SPHK1). Depleting SPHK1 inhibits endocytic recycling, revealing a link between sphingosine metabolism and endocytosis.

Hongying Shen
Francesca Giordano
Pietro De Camilli
Research15 Jun 2014
Nature Cell Biology

Volume: 16, P: 652-662
Methane formation driven by reactive oxygen species across all living organisms

Methane formation by a ROS-mediated process is linked to metabolic activity and is identified as a conserved feature across living systems.

Leonard Ernst
Benedikt Steinfeld
Frank Keppler
Research09 Mar 2022
Nature

Volume: 603, P: 482-487
Mechanisms of Disease: genetics of functional gastrointestinal disorders—searching the genes that matter

It has been suggested that genetic factors are likely to have a major role in the manifestation of functional gastrointestinal disorders. In this Review, the authors consider the evidence available for such a role. They discuss the results of family and twin studies and studies of individual genes thought to be involved in the manifestation of functional gastrointestinal disorders.

Birgit Adam
Tobias Liebregts
Gerald Holtmann
Reviews01 Feb 2007
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 4, P: 102-110
Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance

Nikola Ciganović
Amanuel Wolde-Kidan
Tobias Reichenbach
ResearchOpen Access15 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
Curvature dependence of BAR protein membrane association and dissociation kinetics

Rui Jin
Rui Cao
Tobias Baumgart
ResearchOpen Access10 May 2022
Scientific Reports

Volume: 12, P: 1-9
CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

Su Jung Oh-Hohenhorst
Derya Tilki
Tobias Lange
ResearchOpen Access07 Jan 2021
Cancer Gene Therapy

Volume: 29, P: 49-61
Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

Erdinc Sezgin
Hermann-Josef Kaiser
Ilya Levental
Protocols03 May 2012
Nature Protocols

Volume: 7, P: 1042-1051
A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum

Angela Kranz
Tino Polen
Michael Bott
ResearchOpen Access01 Oct 2022
Scientific Data

Volume: 9, P: 1-10

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Membrane tension and peripheral protein density mediate membrane shape transitions

Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation

Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension

Genomic investigations of unexplained acute hepatitis in children

Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception

Coupling between endocytosis and sphingosine kinase 1 recruitment

Methane formation driven by reactive oxygen species across all living organisms

Mechanisms of Disease: genetics of functional gastrointestinal disorders—searching the genes that matter

Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance

Curvature dependence of BAR protein membrane association and dissociation kinetics

CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum

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