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Advanced filters: Author: Tobias M P Hartwich Clear advanced filters

IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers

Low-antigen-expressing cancers are a challenge to existing chimeric antigen receptor (CAR)-T cell-based therapies. Now, it has been shown that fusion of intrinsically disordered regions to CARs induces CAR condensation and enhances antigen sensitivity and killing activity of CAR-T cells.

Xinyan Zhang
Qian Xiao
Xiaolei Su
ResearchOpen Access29 Sept 2025
Nature Chemical Biology

P: 1-13
Video-rate nanoscopy using sCMOS camera–specific single-molecule localization algorithms

Algorithms that account for and overcome the intrinsic pixel-dependent readout noise from scientific complementary metal-oxide semiconductor (sCMOS) cameras prevent localization artifacts and avoid substantial compromises in localization uncertainty in single-molecule imaging. When combined with multi-emitter fitting, sCMOS cameras allow video-rate single-molecule switching nanoscopy.

Fang Huang
Tobias M P Hartwich
Joerg Bewersdorf
Research26 May 2013
Nature Methods

Volume: 10, P: 653-658
Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells

Min Kang
Kay Yi Chong
Yang Yang-Hartwich
ResearchOpen Access29 May 2020
Oncogenesis

Volume: 9, P: 1-15

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