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Showing 1–3 of 3 results
Advanced filters: Author: Todd A. Anzelon Clear advanced filters

  • Cryo-electron microscopy structures of a PIWI–piRNA complex provide insight into how piRNAs recognise target RNAs and reveal differences from the target mechanisms of microRNAs.

    • Todd A. Anzelon
    • Saikat Chowdhury
    • Ian J. MacRae
    Research
    Nature
    Volume: 597, P: 285-289

  • Eukaryotic Argonaute proteins participate in RNA-guided RNA silencing pathways and are divided into AGO and PIWI clades, with functional and mechanistic differences. Here, the authors show that a deep-branching PIWI protein from Asgard archaea (the closest prokaryotic relatives of eukaryotes) displays hybrid features and may reflect an ancestral molecular architecture that preceded the divergence of eukaryotic AGOs and PIWIs.

    • Carolien Bastiaanssen
    • Pilar Bobadilla Ugarte
    • Fabai Wu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The evolutionarily conserved RNA-binding protein GTSF1 and its homologues interact with members of the PIWI class of Argonaute proteins, increasing the efficiency of the RNA-cleaving activity of PIWI proteins, an essential function across the animal kingdom.

    • Amena Arif
    • Shannon Bailey
    • Phillip D. Zamore
    ResearchOpen Access
    Nature
    Volume: 608, P: 618-625