Nature Search

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

Esposito et al. report a role for bone vascular niche E-selectin in promoting mesenchymal–epithelial transition and Wnt signalling in breast cancer cells, thereby enhancing bone metastasis.

Mark Esposito
Nandini Mondal
Yibin Kang
Research15 Apr 2019
Nature Cell Biology

Volume: 21, P: 627-639
HIV–host interactome revealed directly from infected cells

Fully replication competent HIV-1 viruses engineered to harbour a foreign epitope tag enabled the unbiased characterization of the cellular interactomes of viral Env and Vif proteins during the natural infection of human lymphocytes.

Yang Luo
Erica Y. Jacobs
Mark A. Muesing
Research23 May 2016
Nature Microbiology

Volume: 1, P: 1-15
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1412-1425
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

Genome-wide association meta-analyses among 1.4 million individuals identify 318 new risk loci for type 2 diabetes and provide insight into the contribution of these risk variants to diabetes-related vascular outcomes.

Marijana Vujkovic
Jacob M. Keaton
Danish Saleheen
Research15 Jun 2020
Nature Genetics

Volume: 52, P: 680-691
Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Amendments and Corrections17 Jul 2020
Nature Biotechnology

Volume: 38, P: 1000
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow

Neuron-astrocyte communication plays a key role in pathophysiology, however systematic approaches to unveil it are limited. Here, the authors propose SEARCHIN, a multi-modal integrated workflow, as a tool to identify cross-compartment ligand-receptor interactions, applied to ALS models.

Vartika Mishra
Diane B. Re
Serge Przedborski
ResearchOpen Access04 Nov 2020
Nature Communications

Volume: 11, P: 1-20
Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as well as links to metabolic and cardiovascular diseases.

Raha Pazoki
Marijana Vujkovic
Rachel B. Ramoni
ResearchOpen Access10 May 2021
Nature Communications

Volume: 12, P: 1-12
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

Pavithra Nagarajan
Thomas W. Winkler
Heming Wang
Research04 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3660-3672
Systematic discovery of structural elements governing stability of mammalian messenger RNAs

Secondary structures, or pairing of complementary sequences within RNA, can regulate the binding of proteins that affect transcript stability, splicing, localization, and translation; a computational approach has now been used to discover secondary structures that affect global RNA stability through the binding of specific RNA binding proteins.

Hani Goodarzi
Hamed S. Najafabadi
Saeed Tavazoie
Research08 Apr 2012
Nature

Volume: 485, P: 264-268
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Amendments and Corrections14 Nov 2018
Nature Genetics

Volume: 50, P: 1755
Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken
Karen Ambrose
Rachel Zillwood
Correspondence18 Jun 2020
Nature Biotechnology

Volume: 38, P: 927-931
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

Mehdi Mirzaei
Veer B. Gupta
Vivek K. Gupta
ResearchOpen Access04 Oct 2017
Scientific Reports

Volume: 7, P: 1-16
Unanswered questions in prostate cancer — findings of an international multi-stakeholder consensus by the PIONEER consortium

In this Consensus Statement, the authors present results from an international multi-stakeholder consensus conducted by the PIONEER consortium to identify the most important questions in the field of prostate cancer that could be addressed using big data.

Muhammad Imran Omar
Steven MacLennan
Daniel Kotik
Reviews03 Apr 2023
Nature Reviews Urology

Volume: 20, P: 494-501
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Xuan Wang
Molei Liu
Katherine P. Liao
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-12

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