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Showing 1–15 of 15 results
Advanced filters: Author: Tom F. Lue Clear advanced filters

  • Despite improved understanding of the neural anatomy and advances in surgical techniques, erectile dysfunction remains a common sequela of radical prostatectomy. In this Timeline, leading experts in the field look back at the history of penile rehabilitation after prostatectomy, and discuss the limitations and future perspectives of proposed treatments.

    • Emmanuel Weyne
    • Fabio Castiglione
    • Maarten Albersen
    Reviews
    Nature Reviews Urology
    Volume: 12, P: 289-297

  • Drawing on their own considerable experience, Huang and colleagues, from the University of California, San Francisco, review current therapies and emerging treatments for the management of priapism. Medical and surgical approaches to both the ischemic and nonischemic subtypes of this disorder are discussed.

    • Yun-Ching Huang
    • Ahmed M. Harraz
    • Tom F. Lue
    Reviews
    Nature Reviews Urology
    Volume: 6, P: 262-271

  • The corpus cavernosum is the most important structure for penile erection, and its dysfunction causes physiological and psychological problems. Here the authors perform single-cell RNA-sequencing on corpus cavernosum samples from males with normal erection and erectile dysfunction patients, providing insights into this pathology.

    • LiangYu Zhao
    • Sha Han
    • Zheng Li
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The erectile function domain of the International Index of Erectile Function score is a widely used patient-reported outcome metric and a frequent clinical trial end point. Rosen and colleagues determined minimal clinically important difference (MCID) values for this score to overcome discrepancies between statistical significance and clinical significance. Before these MCIDs are implemented in the clinic, urologists should be aware of the advantages and limitations of this instrument.

    • Maarten Albersen
    • Tom F. Lue
    News & Views
    Nature Reviews Urology
    Volume: 8, P: 591-592

  • Treatment aimed at restoring the underlying tissue and vascular defects that cause erectile dysfunction is sorely lacking. Harraz et al. describe recent advances in the use of gene therapy to improve penile function, highlighting the potential therapeutic benefits. The current status of stem cell research in this area is also discussed.

    • Ahmed Harraz
    • Alan W. Shindel
    • Tom F. Lue
    Reviews
    Nature Reviews Urology
    Volume: 7, P: 143-152

  • A substantial number of women have pelvic floor dysfunction, resulting in urinary and/or faecal incontinence, often many years after vaginal delivery. In this Review, the authors describe the potential of regenerative medicine to repair and regenerate pelvic floor muscles and thus prevent, or ameliorate the symptoms of pelvic floor dysfunction.

    • Geertje Callewaert
    • Marina Monteiro Carvalho Mori Da Cunha
    • Jan Deprest
    Reviews
    Nature Reviews Urology
    Volume: 14, P: 373-385

  • The field of urology has undergone massive changes in the 10 years sinceNature Reviews Urology launched as Nature Clinical Practice Urology. In this Viewpoint, members of the Nature Reviews Urologyadvisory board describe what they think has been the biggest change or issue in urology over the past decade, and give their predictions for the direction of the field over the next 10 years.

    • Maarten Albersen
    • Rufus Cartwright
    • Dan Theodorescu
    Reviews
    Nature Reviews Urology
    Volume: 11, P: 649-655

  • The EAU has issued the first clinical practice guidelines on priapism, which have been published in short form in European Urology. Put together by the EAU panel on male sexual dysfunction, these guidelines provide an accessible, structured guide for the diagnosis and treatment of this rare clinical disorder.

    • Maarten Albersen
    • Trinity J. Bivalacqua
    News & Views
    Nature Reviews Urology
    Volume: 11, P: 132-134

  • Erectile dysfunction remains a frequent sequela of radical prostatectomy, owing to injury to the cavernous nerves that innervate the penile erectile tissue. Over the last decade, many strategies have been proposed to minimize the duration of denervation and prevent irreversible structural changes from occurring in the corpora cavernosa.

    • Emmanuel Weyne
    • Maarten Albersen
    News & Views
    Nature Reviews Urology
    Volume: 11, P: 616-618

  • Low-intensity extracorporeal shockwave therapy (Li-ESWT) has gained popularity as a noninvasive treatment for erectile dysfunction (ED), with the potential to cure, rather than simply provide symptomatic relief. However, the quality of data regarding this treatment option is variable, and drawing conclusions is a challenge. In this Review, a team of expert authors describe the rationale and potential mechanisms of Li-ESWT for ED and discuss the available evidence for its clinical use.

    • Mikkel Fode
    • Georgios Hatzichristodoulou
    • Maarten Albersen
    Reviews
    Nature Reviews Urology
    Volume: 14, P: 593-606

  • Men with erectile dysfunction (ED) that is unresponsive to available oral pharmacotherapy with PDE5 inhibitors represent a significant subgroup of patients with the disorder. Such patients might in the near future benefit from regenerative medicine options that restore tissue integrity and signalling in penis-projecting neurons, penile smooth muscle cells and endothelial cells. In this comprehensive Review, the authors discuss the current cutting-edge research in regenerative medicine for ED and consider the therapeutic potential of these techniques for the future.

    • Lukman Hakim
    • Frank Van der Aa
    • Maarten Albersen
    Reviews
    Nature Reviews Urology
    Volume: 9, P: 520-536