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Showing 1–3 of 3 results

Advanced filters: Author: Tomas Strandin Clear advanced filters

Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants

Here the authors describe a small antibody-like protein that can prevent infection by diverse SARS-CoV-2 variants in cell culture and in mice that were intranasally treated with this inhibitor before or shortly after being exposed to the virus.

Anna R. Mäkelä
Hasan Uğurlu
Kalle Saksela
ResearchOpen Access24 Mar 2023
Nature Communications

Volume: 14, P: 1-12
Signal peptide mimicry primes Sec61 for client-selective inhibition

A selective inhibitor of Sec61 blocks protein entry into the secretory pathway and has therapeutic efficacy in rheumatoid arthritis. A cryo-EM structure of the inhibited Sec61 provides a model for client-selective protein translocation inhibition.

Shahid Rehan
Dale Tranter
Ville O. Paavilainen
ResearchOpen Access11 May 2023
Nature Chemical Biology

Volume: 19, P: 1054-1062
Uncovering the mysteries of hantavirus infections

Vaheri and colleagues discuss the molecular and cell biology of hantavirus infection and provide an overview of the virus-induced and immune-mediated pathology caused by this virus family in humans.

Antti Vaheri
Tomas Strandin
Jukka Mustonen
Reviews16 Jul 2013
Nature Reviews Microbiology

Volume: 11, P: 539-550