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Showing 1–4 of 4 results
Advanced filters: Author: Tommaso Cavazza Clear advanced filters

  • Analysis of early human embryos reveals that DNA duplication after fertilization is highly inefficient. This causes DNA damage, chromosome breaks and abnormal numbers of chromosomes, impairing embryo development.

    • Tommaso Cavazza
    • Melina Schuh
    News & Views
    Nature
    Volume: 609, P: 683-684

  • In a newly fertilized egg, maternal and paternal chromosomes are enclosed in two separate pronuclei but the mechanisms in mammals for pronuclear movement are unclear. Here, the authors report that both F-actin and microtubule polymerization act in concern to drive inward movement of pronuclei towards the cell centre.

    • Kathleen Scheffler
    • Julia Uraji
    • Melina Schuh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • chTOG, a microtubule polymerase, interacts with TACC3 during mitosis to regulate spindle formation. By studying their Xenopus homologues, Mortuza et al. discover that one TACC3 recruits two chTOG molecules to the spindle, increasing its local concentration and promoting microtubule elongation.

    • Gulnahar B. Mortuza
    • Tommaso Cavazza
    • Guillermo Montoya
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12