Nature Search

Decentralized circadian clocks process thermal and photoperiodic cues in specific tissues

Circadian clocks regulate many biological processes. The authors show the existence of two decentralized tissue-specific clocks: one in the vasculature for photoperiodic control of flowering, one in the epidermis for temperature-dependant elongation.

Hanako Shimizu
Kana Katayama
Motomu Endo
Research02 Nov 2015
Nature Plants

Volume: 1, P: 1-6
Rituximab-induced long-term remission in childhood-onset, uncomplicated, frequently relapsing or steroid-dependent nephrotic syndrome: a randomized, placebo-controlled trial and a follow-up study

Kazumoto Iijima
Mayumi Sako
Mari Oba
ResearchOpen Access10 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

XBB.1.5 of SARS-CoV-2 is a descendant of XBB.1 and has mutations in spike and ORF8, making it more infectious to humans. Here, the authors examined in detail the differences in virological properties of the two variants.

Tomokazu Tamura
Takashi Irie
Takasuke Fukuhara
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-17
A protein language model for exploring viral fitness landscapes

Ito et al. present CoVFit, an AI model that predicts variant fitness (transmissibility) from spike protein sequences alone. They further demonstrate its utility in forecasting viral evolution via single amino acid mutations.

Jumpei Ito
Adam Strange
Kei Sato
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-16
High Ambient Pressure Produces Hypertrophy and Up-Regulates Cardiac Sarcoplasmic Reticulum Ca²⁺ Regulatory Proteins in Cultured Rat Cardiomyocytes

Takashi Sato
Tomoko Ohkusa
Masunori Matsuzaki
Research01 Dec 2006
Hypertension Research

Volume: 29, P: 1013-1020
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.

Tomokazu Tamura
Jumpei Ito
Kei Sato
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-20
Effect of extramedullary disease on allogeneic hematopoietic cell transplantation for pediatric acute myeloid leukemia: a nationwide retrospective study

Hirotoshi Sakaguchi
Takako Miyamura
Yoshiko Atsuta
Research10 Mar 2021
Bone Marrow Transplantation

Volume: 56, P: 1859-1865
Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Hisano Yajima
Yuki Anraku
Takao Hashiguchi
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Recent Omicron SARS-CoV-2 subvariants independently acquire 5 key Spike mutations. Here, the authors evaluate the evolutionary importance of the 5 mutations and characterize the virological properties of variant BQ.1.1 harboring all 5 mutations.

Jumpei Ito
Rigel Suzuki
Kei Sato
ResearchOpen Access11 May 2023
Nature Communications

Volume: 14, P: 1-20
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

The virological and pathological features of Omicron subvariants are compared in in vitro cellular and airway-on-a-chip and in vivo hamster models.

Tomokazu Tamura
Daichi Yamasoba
Takasuke Fukuhara
ResearchOpen Access24 Jul 2023
Communications Biology

Volume: 6, P: 1-12
Comprehensive serum glycopeptide spectra analysis to identify early-stage epithelial ovarian cancer

Mikio Mikami
Kazuhiro Tanabe
Koji Matsuo
ResearchOpen Access28 Aug 2024
Scientific Reports

Volume: 14, P: 1-16
Polymer coating glass to improve the protein antifouling effect

Random copolymers (P(M_100-m/T_m)) composed of 2-methacryloyloxyethyl phosphorylcholine, which suppresses protein fouling, and 3-(triethoxysilyl)propyl methacrylate, which can react covalently to the glass surface, were prepared via photoinitiated radical polymerization. Coating of the glass with P(M_100-m/T_m) was confirmed by red fluorescence from Rhodamine 6G. The protein antifouling properties of the P(M_100-m/T_m) coating on glass were confirmed using fluorescence-labeled proteins.

Tomoko Honda
Aiko Nakao
Shin-ichi Yusa
Research19 Feb 2018
Polymer Journal

Volume: 50, P: 381-388
Intracellular pH affects mitochondrial homeostasis in cultured human corneal endothelial cells prepared for cell injection therapy

Hideto Deguchi
Tomoko Yamashita
Junji Hamuro
ResearchOpen Access15 Apr 2022
Scientific Reports

Volume: 12, P: 1-14
Neutralizing immunity against coronaviruses in Tanzanian health care workers

Godfrey Barabona
Isaac Ngare
Takamasa Ueno
ResearchOpen Access06 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage

Mami Kusaka
Tomoko Hasegawa
Akitaka Tsujikawa
ResearchOpen Access28 Sept 2022
Scientific Reports

Volume: 12, P: 1-13
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13

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