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Showing 1–2 of 2 results
Advanced filters: Author: Tomoko Tujimura Clear advanced filters

  • GCN5 inhibits hepatic gluconeogenesis through acetylation of PGC-1α. Here the authors show that GCN5 also activates hepatic gluconeogenesis by acetylating histone H3K9, and that the affinity of GCN5 for its different substrates is regulated via phosphorylation at S275 by PKA in a CITED2-dependent manner.

    • Mashito Sakai
    • Tomoko Tujimura-Hayakawa
    • Michihiro Matsumoto
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • Dysregulated hepatic glucose production (HGP) is a key feature of type 2 diabetes (T2D). Masato Kasuga and his colleagues now show that under physiological conditions, the expression and activity of the protein CITED2 in the liver is altered in response to hormonal cues that regulate HGP. They also show in a mouse model of T2D that hepatic CITED2 expression is elevated and that its genetic knockdown reduces serum glucose concentrations, suggesting this protein as a possible therapeutic target in the clinic.

    • Mashito Sakai
    • Michihiro Matsumoto
    • Masato Kasuga
    Research
    Nature Medicine
    Volume: 18, P: 612-617