Peripheral mechanisms of pain in osteoarthritis include nociceptor sensitization via the function of ion channels and pro-inflammatory molecules, and, potentially, pathways supporting neuronal growth and differentiation within the diseased joint. This Review discusses how neuronal trophism and neurovascular remodelling could be targeted in combination with neuronal de-sensitization or joint re-structuring approaches to reduce osteoarthritic pain.
- Vicky Batchelor
- Thomas A. Perry
- Tonia L. Vincent
