Nature Search

Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer

Using genetically engineered models, Genovese and colleagues study patterns of convergent evolution in renal cancer, and pinpoint dysregulation of interferon signaling as a means of adaptation to chromosomal instability in metastatic progression.

Luigi Perelli
Federica Carbone
Giannicola Genovese
ResearchOpen Access26 Jun 2023
Nature Cancer

Volume: 4, P: 984-1000
RNA-binding proteins regulate the expression of the immune activating ligand MICB

The expression of stress-induced ligands and their recognition by the NKG2D-activating receptor is important for the elimination of virally infected and cancerous cells by cytotoxic lymphocytes. Here, the authors provide insights into the post-transcriptional mechanism regulating the expression of the NKG2D ligand, MICB.

Daphna Nachmani
Tony Gutschner
Ofer Mandelboim
Research13 Jun 2014
Nature Communications

Volume: 5, P: 1-13
Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by activating Yap through a RhoA/MYPT-PP1 pathway.

Monika Haemmerle
Morgan L. Taylor
Anil K. Sood
ResearchOpen Access21 Aug 2017
Nature Communications

Volume: 8, P: 1-15
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.

Prasenjit Dey
Joelle Baddour
Ronald A. DePinho
Research18 Jan 2017
Nature

Volume: 542, P: 119-123
Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.

Giannicola Genovese
Alessandro Carugo
Lynda Chin
Research08 Feb 2017
Nature

Volume: 542, P: 362-366
MALAT1: a therapeutic candidate for a broad spectrum of vascular and cardiorenal complications

Prasanth Puthanveetil
Tony Gutschner
Johan Lorenzen
Reviews19 Dec 2019
Hypertension Research

Volume: 43, P: 372-379
Extravesicular TIMP-1 is a non-invasive independent prognostic marker and potential therapeutic target in colorectal liver metastases

Venkatesh Sadananda Rao
Qianyu Gu
Christoph Kahlert
ResearchOpen Access09 Feb 2022
Oncogene

Volume: 41, P: 1809-1820
Going only half the way: cell cycle exit after the G1 restriction point

Lisa Müller
Tony Gutschner
Mechthild Hatzfeld
Research HighlightsOpen Access01 Dec 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-2

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