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Showing 1–6 of 6 results
Advanced filters: Author: Torben Gehring Clear advanced filters

  • MALT1 regulates NFκB signalling both as a scaffolding protein and as a protease. Here the authors show that during T cell activation the expression of MALT1 gene switches to an alternatively spliced variant, which increases TCR signal transduction due to enhanced TRAF6 binding.

    • Isabel Meininger
    • Richard A. Griesbach
    • Daniel Krappmann
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • The differentiation and function of regulatory T (Treg) cells are critically controlled by T cell receptor (TCR) signaling. Here the authors show that CARD11-BCL10-MALT1 (CBM) complexes are dispensable for effector Treg conversion under inflammatory conditions but are critical for mediating Treg suppressive activity in a MALT1 paracaspase-dependent manner.

    • Marc Rosenbaum
    • Andreas Gewies
    • Jürgen Ruland
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation of pathogenic Th17 cells and susceptibility to a mouse model of multiple sclerosis.

    • Jonathan J. Cho
    • Zhiwei Xu
    • Dorina Avram
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18

  • The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.

    • Florian Schlauderer
    • Thomas Seeholzer
    • Katja Lammens
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12