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Showing 1–7 of 7 results
Advanced filters: Author: Tore Bleckwehl Clear advanced filters

  • While inductive signals controlling germline specification are well characterized, the intrinsic factors that allow epiblast cells to respond to such signals remain largely unknown. Here the authors use in vitro differentiated primordial germ cells to show that partial retention of histone H3K4 monomethylation within relevant enhancers is important for germline competence and specification.

    • Tore Bleckwehl
    • Giuliano Crispatzu
    • Álvaro Rada-Iglesias
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Poised enhancers (PEs) in embryonic stem cells have accessible chromatin, are bound by repressive Polycomb Group proteins, and interact with their targets prior to activation. However, whether this is recapitulated in vivo is unknown. Here the authors show PEs display these features in mouse embryos, are prevalent across vertebrates, and are required for developmental gene expression.

    • Giuliano Crispatzu
    • Rizwan Rehimi
    • Alvaro Rada-Iglesias
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Here the authors establish and benchmark a single cell RNA multiplexing framework that enables simple, yet robust high-throughput multiplexing leveraging single cell nucleotide polymorphisms of patients.

    • Konrad Hoeft
    • Tore Bleckwehl
    • Rafael Kramann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-7

  • A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling to cardiac fibroblasts, highlighting a role for immunomodulators in targeting cardiac fibrosis.

    • Junedh M. Amrute
    • Xin Luo
    • Kory J. Lavine
    Research
    Nature
    Volume: 635, P: 423-433

  • MYC regulates numerous genes involved in cell growth and proliferation. Here, Li-Bao et al. study the DNA regions that regulate Myc transcription in early mouse embryos and pluripotent stem cells. They report a specific region with independent modules dedicated to discrete temporal and spatial phases of Myc expression.

    • Lin Li-Bao
    • Covadonga Díaz-Díaz
    • Miguel Torres
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17