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Advanced filters: Author: Torey Jones Clear advanced filters
  • Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubstituted imidazole CU-CPD107 with dichotomous behaviour, which inhibits R848-induced TLR8 signaling, but shows synergistic activity in the presence of ssRNA, making it a potential antiviral agent.

    • Yi Yang
    • Adam Csakai
    • Hang Yin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9