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Showing 1–3 of 3 results
Advanced filters: Author: Toshiki G Nakashige Clear advanced filters

  • Lectins are non-enzymatic carbohydrate binding proteins important to human cellular functions. Here, the authors characterize a lectin produced by a human associated bacterium, and show that interacts with myeloid cells in the blood and intestine, suggesting commensal microbiota lectins as a diverse and widespread mechanism to interact with host physiology.

    • Louis J. Cohen
    • Sun M. Han
    • Sean F. Brady
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Membrane anchoring protects metallo-β-lactamase NDM-1 from degradation while favoring its secretion into outer-membrane vesicles. This provides carbapenem resistance to bacteria that are sensitive to zinc starvation, which causes degradation of these enzymes.

    • Lisandro J González
    • Guillermo Bahr
    • Alejandro J Vila
    Research
    Nature Chemical Biology
    Volume: 12, P: 516-522

  • Calprotectin sequesters manganese and zinc from bacteria, preventing their growth. Spectroscopic and biological data show it also chelates iron with sub-picomolar affinity using a hexahistidine motif, establishing a new mechanism for its antibacterial activity.

    • Toshiki G Nakashige
    • Bo Zhang
    • Elizabeth M Nolan
    Research
    Nature Chemical Biology
    Volume: 11, P: 765-771