Mimasu et al. report a rat full-length structure of kynurenine 3-monooxygenase (KMO) in its membrane-embedded form, complexed with two inhibitors. They find that the dimeric interface of KMO is critical for its activity. This study provides insights into the drug development strategies that target KMO, an important regulator of tryptophan metabolism.
- Shinya Mimasu
- Hiroaki Yamagishi
- Kenichi Kakefuda
