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Hypertension Research (31)
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Showing 1–50 of 119 results

Advanced filters: Author: Toshio Kobayashi Clear advanced filters

Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
Postsynaptic modulation of excitatory process in sympathetic ganglia by cyclic AMP

HARUO KOBAYASHI
TOSHIO HASHIGUCHI
NAKAKO S. USHIYAMA
Research01 Jan 1978
Nature

Volume: 271, P: 268-270
Does cyclic GMP mediate the slow excitatory synaptic potential in sympathetic ganglia?

TOSHIO HASHIGUCHI
NAKAKO S. USHIYAMA
BENJAMIN LIBET
Research01 Jan 1978
Nature

Volume: 271, P: 267-268
Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404

Azusa Aoyagi
Mariko Ito-Kobayashi
Toshio Takatsu
Research01 Mar 2008
The Journal of Antibiotics

Volume: 61, P: 136-141
Formation of ‘Protoplasts’ in Mutant Strains of Salmonella induced by Galactose

TOSHIO FUKASAWA
HIROSHI NIKAIDO
Research18 Apr 1959
Nature

Volume: 183, P: 1131-1132
Ca²⁺ -calmodulin-dependent phosphorylation and platelet secretion

Masakatsu Nishikawa
Toshio Tanaka
Hiroyoshi Hidaka
Research30 Oct 1980
Nature

Volume: 287, P: 863-865
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Endothelial Progenitor Cell Differentiation and Senescence in an Angiotensin II-Infusion Rat Model

Katsunobu Kobayashi
Toshio Imanishi
Takashi Akasaka
Research01 Jun 2006
Hypertension Research

Volume: 29, P: 449-455
Effect of Acidosis on Contractile Function in the Newborn Rabbit Heart

Toshio Nakanishi
Hirofumi Okuda
Atsuyoshi Takao
Research01 May 1985
Pediatric Research

Volume: 19, P: 482-488
A cross sectional study of the relationship between clinical scores and timing of guidance for resident physicians in outpatient settings

Taiju Miyagami
Yuji Nishizaki
Yasuharu Tokuda
ResearchOpen Access01 Dec 2025
Scientific Reports

Volume: 16, P: 1-8
cis-Vinyl-1:1 Polymer of Butadiene

Junji Furukawa
Kazuo Haga
Kazuhiko Sakamoto
Research01 May 1971
Polymer Journal

Volume: 2, P: 371-378
Exploration of novel αβ-protein folds through de novo design

Here the authors carry out a systematic de novo protein design exploration of novel αβ-folds predicted under a defined set of rules for β-sheet topology, in an effort to find out the extent to which all possible αβ-folds are already sampled in nature.

Shintaro Minami
Naohiro Kobayashi
Nobuyasu Koga
ResearchOpen Access03 Jul 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1132-1140
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Sterenin A, B, C and D, Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors from Stereum sp. SANK 21205

Mariko Ito-Kobayashi
Azusa Aoyagi
Toshio Takatsu
Research01 Mar 2008
The Journal of Antibiotics

Volume: 61, P: 128-135
Estimation of the effective reproduction number of influenza based on weekly reports in Miyazaki Prefecture

Takenori Yamauchi
Shouhei Takeuchi
Toshio Nakadate
ResearchOpen Access22 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes

In C-glycosides the sugar moiety is linked through a carbon-carbon bond to the non-sugar moiety, which can be cleaved by intestinal microbes. Here, the authors use bioinformatics analysis to identify C-glycoside deglycosidase enzymes in intestinal and soil bacteria, biochemically characterise them and determine their structures and probe catalytic important residues in mutagenesis experiments.

Takahiro Mori
Takuto Kumano
Michihiko Kobayashi
ResearchOpen Access02 Nov 2021
Nature Communications

Volume: 12, P: 1-12
Design of complicated all-α protein structures

Here authors developed a computational method to design complicated all-α structures using typical helix–loop–helix motifs and canonical α-helices, and demonstrated the ability to create complicated all-α proteins.

Koya Sakuma
Naohiro Kobayashi
Nobuyasu Koga
ResearchOpen Access04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 275-282
Effect of Estrogen on Differentiation and Senescence in Endothelial Progenitor Cells Derived from Bone Marrow in Spontaneously Hypertensive Rats

Toshio Imanishi
Katsunobu Kobayashi
Ichiro Nishio
Research01 Sept 2005
Hypertension Research

Volume: 28, P: 763-772
Cosmids and transcribed sequences from chromosome 11q23

Motonobu Katoh
Yuzuki Nakagawa
Mitsuo Oshimura
Research01 Dec 1995
Japanese journal of human genetics

Volume: 40, P: 307-317
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Efficacy of Azelnidipine on Home Blood Pressure and Pulse Rate in Patients with Essential Hypertension: Comparison with Amlodipine

Toshio Yamagishi
Research01 Oct 2006
Hypertension Research

Volume: 29, P: 767-773
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

Norihiro Kato and colleagues perform a meta-analysis of genome-wide association studies to identify common variants associated with blood pressure variation in east Asians. They identify five new genome-wide significant signals and replicate seven loci previously discovered in populations of European ancestry.

Norihiro Kato
Fumihiko Takeuchi
Jiang He
Research15 May 2011
Nature Genetics

Volume: 43, P: 531-538
Clinical Efficacy of a New Angiotensin II Type 1 Receptor Blocker, Pratosartan, in Hypertensive Patients

Toshio Ogihara
Takao Saruta
Hiromi Rakugi
Research01 Feb 2008
Hypertension Research

Volume: 31, P: 281-287
Aliskiren, a Novel Oral Renin Inhibitor, Provides Dose-Dependent Efficacy and Placebo-Like Tolerability in Japanese Patients with Hypertension

Toshio Kushiro
Hiroshige Itakura
Deborah L Keefe
Research01 Dec 2006
Hypertension Research

Volume: 29, P: 997-1005
Erratum to: Combined Effects of an 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor and Angiotensin II Receptor Antagonist on Nitric Oxide Bioavailability and Atherosclerotic Change in Myocardial Infarction—Prone Watanabe Heritable Hyperlipidemic Rabbits

Toshio Imanishi
Hideyuki Ikejima
Takashi Akasaka
Amendments and Corrections01 Aug 2008
Hypertension Research

Volume: 31, P: 1677
Polymerization of Methyl Methacrylate Initiated by Benzenesulfinic Acid

Toshio Watanabe
Kazuyoshi Sakai
Makoto Takeishi
Research01 Sept 1995
Polymer Journal

Volume: 27, P: 969-973
N-Substituted-2-propynamides. Highly Reactive Acetylene Derivatives toward Hydrogen Migration Polymerization

Ryoji Nomura
Hideo Nakako
Toshio Masuda
Research01 Mar 2000
Polymer Journal

Volume: 32, P: 303-305
Palladium(0)-catalyzed Synthesis of Unsaturated Polyethers from Bifunctional Vinyloxiranes and Bisphenol Analogues

Toshio Koizumi
Tadayoshi Akita
Takeshi Endo
Research10 Aug 2004
Polymer Journal

Volume: 36, P: 647-651
Palladium(0)-Catalyzed Synthesis of Unsaturated Polyesters from Bifunctional Vinyloxirane and Diacids

Toshio Koizumi
Tadayoshi Akita
Takeshi Endo
Research01 Mar 2003
Polymer Journal

Volume: 35, P: 266-269
Jam1a–Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Notch signalling has a key role in the generation of haematopoietic stem cells (HSCs) during vertebrate development; here two adhesion molecules, Jam1a and Jam2a, are shown to be essential for the contact between precursors of HSCs and the somite during embryonic migration, and the Jam1a–Jam2a interaction is shown to be needed to transmit the Notch signal and produce HSCs.

Isao Kobayashi
Jingjing Kobayashi-Sun
David Traver
Research13 Aug 2014
Nature

Volume: 512, P: 319-323
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

Takako Koga
Masanori Inui
Toshiyuki Takai
Research15 Apr 2004
Nature

Volume: 428, P: 758-763
Synergistic Fungicidal Activities of Amphotericin B and N-Methyl-N″-dodecylguanidine: A Constituent of Polyol Macrolide Antibiotic Niphimycin

Akira Ogita
Keiji Matsumoto
Toshio Tanaka
Research01 Jan 2007
The Journal of Antibiotics

Volume: 60, P: 27-35
Effects of Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Antagonist Combination on Nitric Oxide Bioavailability and Atherosclerotic Change in Watanabe Heritable Hyperlipidemic Rabbits

Toshio Imanishi
Akio Kuroi
Takashi Akasaka
Research01 Mar 2008
Hypertension Research

Volume: 31, P: 575-584
Pioglitazone Inhibits Angiotensin II–Induced Senescence of Endothelial Progenitor Cell

Toshio Imanishi
Katsunobu Kobayashi
Takashi Akasaka
Research01 Apr 2008
Hypertension Research

Volume: 31, P: 757-765
Combined Effects of an 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor and Angiotensin II Receptor Antagonist on Nitric Oxide Bioavailability and Atherosclerotic Change in Myocardial Infarction-Prone Watanabe Heritable Hyperlipidemic Rabbits

Toshio Imanishi
Hideyuki Ikejima
Takashi Akasaka
Research01 Jun 2008
Hypertension Research

Volume: 31, P: 1199-1208
Effects of Pioglitazone on Nitric Oxide Bioavailability Measured Using a Catheter-Type Nitric Oxide Sensor in Angiotensin II−Infusion Rabbit

Toshio Imanishi
Akio Kuroi
Takashi Akasaka
Research01 Jan 2008
Hypertension Research

Volume: 31, P: 117-125
Novel Zwitterionic Alternating Copolymerization of Substituted Acetylenes with 2-Methyl-2-oxazoline

Ryoji Nomura
Yuji Shintaku
Toshio Masuda
Research01 Oct 2000
Polymer Journal

Volume: 32, P: 904-906
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Transvalencin Z, a New Antimicrobial Compound with Salicylic Acid Residue from Nocardia transvalensis IFM 10065

Akira Mukai
Toshio Fukai
Yuzuru Mikami
Research01 Jun 2006
The Journal of Antibiotics

Volume: 59, P: 366-369
Novel Group 6 Transition Metal Catalysts, MCl₂(CO)₃(AsPh₃)₂ (M=W, Mo), for the Metathesis Polymerization of Substituted Acetylenes

Hideo Nakako
Yoshihiko Misumi
Gabor Szalai
Research01 Jul 1998
Polymer Journal

Volume: 30, P: 577-580
Carbon Whisker as an Initiator of Cationic Polymerization of N-Vinylcarbazole and N-Vinyl-2-pyrrolidone

Norio Tsubokawa
Toshio Yoshihara
Research01 Mar 1991
Polymer Journal

Volume: 23, P: 177-183
Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

The role of macrophages in hypertension-induced arterial remodeling is poorly understood. Here, Sumida et al. show that high blood pressure drives the alternatively activated macrophages to secrete complement C1q protein, which in turn elicits proliferative β-catenin signalling in the arterial smooth muscle cells.

Tomokazu Sumida
Atsuhiko T. Naito
Issei Komuro
ResearchOpen Access26 Feb 2015
Nature Communications

Volume: 6, P: 1-12
Living Metathesis Polymerization of Several Substituted Acetylenes by MoOCl₄–Et₃Al–EtOH

Hisayasu Kaneshiro
Shigetaka Hayano
Toshio Masuda
Research01 Apr 1999
Polymer Journal

Volume: 31, P: 348-352
Polymerization of Methyl Methacrylate Initiated by Arylsulfinic Acids

Toshio Watanabe
Kazuyoshi Sakai
Makoto Takeishi
Research01 Jun 1997
Polymer Journal

Volume: 29, P: 487-491
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Linkage and haplotype analysis of familial early-onset Alzheimer disease in Japanese population

Kouzin Kamino
Keiko Nagano
Toshio Ogihara
Research01 Sept 1995
Japanese journal of human genetics

Volume: 40, P: 229-241
Antihypertensive Efficacy and Safety of Fixed-Dose Combination Therapy with Losartan plus Hydrochlorothiazide in Japanese Patients with Essential Hypertension

Takao Saruta
Toshio Ogihara
Kihito Takahashi
Research01 Aug 2007
Hypertension Research

Volume: 30, P: 729-739
A repeat unit of Vibrio diarrheal T3S effector subverts cytoskeletal actin homeostasis via binding to interstrand region of actin filaments

Mitsuhiro Nishimura
Takashi Fujii
Tetsuya Iida
ResearchOpen Access03 Jun 2015
Scientific Reports

Volume: 5, P: 1-8

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