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Showing 1–11 of 11 results
Advanced filters: Author: Tracy Tabib Clear advanced filters

  • The tumor microenvironment (TME) has an important role in Head and Neck Squamous Cell Carcinoma (HNSCC) progression. Here, using single-cell RNA sequencing and multiplexed imaging, the authors report the cellular complexity of the TME in patients with HNSCC, exploring inflammatory status, stromal heterogeneity and immune checkpoint receptor-ligand interactions.

    • Cornelius H. L. Kürten
    • Aditi Kulkarni
    • Robert L. Ferris
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.

    • Tracy Tabib
    • Mengqi Huang
    • Robert Lafyatis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Exhausted T cells are associated with inefficient viral clearance, tumor immunity and response to immunotherapy. Here the authors show CD8+ T cells in the pancreatic islets have a LAG3-promoted ‘restrained’ phenotype resembling exhausted cells but maintain effector functions, and LAG3 expression limits pathology in the nonobese diabetic mouse model of type 1 diabetes.

    • Stephanie Grebinoski
    • Qianxia Zhang
    • Dario A. A. Vignali
    Research
    Nature Immunology
    Volume: 23, P: 868-877

  • Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in patients with head and neck squamous cell carcinoma and demonstrate that TLS with germinal centres are associated with better survival.

    • Ayana T. Ruffin
    • Anthony R. Cillo
    • Tullia C. Bruno
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Regulatory T cells obstruct effective anti-cancer immune responses. Vignali and colleagues demonstrate that IL-10 production and IL-35 production by tumor-infiltrating regulatory T cells mediate differential and non-redundant suppressive effects on tumor-reactive cytotoxic T cells.

    • Deepali V. Sawant
    • Hiroshi Yano
    • Dario A. A. Vignali
    Research
    Nature Immunology
    Volume: 20, P: 724-735

  • Developmental disorders (DDs) are more prevalent in males, thought to be due to X-linked genetic variation. Here, the authors investigate the burden of X-linked coding variants in 11,044 DD patients, showing that this contributes to ~6% of both male and female cases and therefore does not solely explain male bias in DDs.

    • Hilary C. Martin
    • Eugene J. Gardner
    • Matthew E. Hurles
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

    • Lisa Sikkema
    • Ciro Ramírez-Suástegui
    • Fabian J. Theis
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1563-1577