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Showing 1–4 of 4 results
Advanced filters: Author: Travis Faust Clear advanced filters

  • PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunotherapeutic approaches for treatment.

    • Pinar Ayata
    • Jessica M. Crowley
    • Anne Schaefer
    ResearchOpen Access
    Nature
    Volume: 648, P: 157-165

  • Neuregulin-1 and DISC1 signalling pathways have both been linked to neurodevelopment and schizophrenia. Here, Seshadri et al. demonstrate that DISC1 negatively regulates NRG1-induced ErbB4 signalling in adult cortical interneurons both in vitro and in vivo, possibly via competitive binding to PSD95.

    • Saurav Seshadri
    • Travis Faust
    • Akira Sawa
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Neural circuits in the mammalian central nervous system are modified in response to neural activity during development. In this Review, Faust and colleagues provide an overview of the mechanisms underlying developmental synaptic pruning and how alterations in this process can occur in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia.

    • Travis E. Faust
    • Georgia Gunner
    • Dorothy P. Schafer
    Reviews
    Nature Reviews Neuroscience
    Volume: 22, P: 657-673