Major histocompatibility complex peptides function as olfactory cues for vomeronasal sensory neurons (VSNs) in the mammalian nose. Here, the authors report that individual VSNs expressing the receptor gene V2r1b have broad peptide responsiveness, but sufficient specificity to distinguish peptides differing by a single amino acid residue. Furthermore, they find that targeted disruption of V2r1b eliminates the VSN peptide response.
- Trese Leinders-Zufall
- Tomohiro Ishii
- Thomas Boehm
