MicroRNAs (miRNAs) have emerged as key regulators of bone development, remodeling and pathologies. This Review discusses the critical functions of miRNAs controlling skeletal cell commitment, growth and differentiation. The authors present novel insights into the supervision of chondro-osteogenic signaling pathways and transcriptional regulatory networks that are coordinated for normal bone homeostasis.
- Jane B. Lian
- Gary S. Stein
- Ying Zhang