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Showing 1–5 of 5 results
Advanced filters: Author: Trisha Bhattacharya Clear advanced filters
  • Biaryls are privileged structural motif used in the discovery and design of therapeutics with high affinity and specificity for a broad range of protein targets. Herein, the authors develop a robust strategy for para-C–H arylation of arenes with a range of (het)aryl iodides, including bioactive molecules.

    • Sudip Maiti
    • Yingzi Li
    • Debabrata Maiti
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10
  • Electrophilic acylation of arenes is largely limited to electron rich systems, non-polar medium and often displays moderate selectivity. Here, the authors show a directed para-selective ketonisation of arenes, overriding electronic bias and structural congestion, and apply it to the synthesis of bioactive compounds.

    • Arun Maji
    • Amit Dahiya
    • Debabrata Maiti
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10
  • The role of keratinocyte subpopulations in the different phases of the viral cycle during HPV16 infection remains to be characterised. Here, single cell RNA sequencing of HPV16 infected and uninfected organoids identifies 12 distinct keratinocyte populations including an HPV-reprogrammed keratinocyte subpopulation that is linked to cancer.

    • Mary C. Bedard
    • Tafadzwa Chihanga
    • Susanne I. Wells
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20
  • Transient directing groups enable selective metal-catalysed C–H functionalization reactions to give diverse products. These directing groups form and dissociate in situ, such that their use is an efficient route to complex organics, examples of which are summarized in this Review.

    • Nupur Goswami
    • Trisha Bhattacharya
    • Debabrata Maiti
    Reviews
    Nature Reviews Chemistry
    Volume: 5, P: 646-659