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Showing 1–13 of 13 results
Advanced filters: Author: Tristan Pearce Clear advanced filters

  • Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

    • William Hill
    • Emilia L. Lim
    • Charles Swanton
    Research
    Nature
    Volume: 616, P: 159-167

  • Analyses of the TRACERx study unveil the relationship between tissue morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk of lung adenocarcinomas.

    • Takahiro Karasaki
    • David A. Moore
    • Mariam Jamal-Hanjani
    Research
    Nature Medicine
    Volume: 29, P: 833-845

  • Results of the TRACERx study shed new light into the association between body composition and body weight with survival in individuals with non-small cell lung cancer, and delineate potential biological processes and mediators contributing to the development of cancer-associated cachexia.

    • Othman Al-Sawaf
    • Jakob Weiss
    • Charles Swanton
    Research
    Nature Medicine
    Volume: 29, P: 846-858

  • Computational and machine-learning approaches that integrate genomic and transcriptomic variation from paired primary and metastatic non-small cell lung cancer samples from the TRACERx cohort reveal the role of transcriptional events in tumour evolution.

    • Carlos Martínez-Ruiz
    • James R. M. Black
    • Nicholas McGranahan
    ResearchOpen Access
    Nature
    Volume: 616, P: 543-552

  • Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

    • Christopher Abbosh
    • Alexander M. Frankell
    • Charles Swanton
    Research
    Nature
    Volume: 616, P: 553-562

  • A longitudinal evolutionary analysis of 126 lung cancer patients with metastatic disease reveals the timing of metastatic divergence, modes of dissemination and the genomic events subject to selection during the metastatic transition.

    • Maise Al Bakir
    • Ariana Huebner
    • Charles Swanton
    ResearchOpen Access
    Nature
    Volume: 616, P: 534-542

  • Analyses of multiregional tumour samples from 421 patients with non-small cell lung cancer prospectively enrolled to the TRACERx study reveal determinants of tumour evolution and relationships between intratumour heterogeneity and clinical outcome.

    • Alexander M. Frankell
    • Michelle Dietzen
    • Charles Swanton
    ResearchOpen Access
    Nature
    Volume: 616, P: 525-533

  • Indigenous knowledge and experience have historically been under-represented in the IPCC's reports. New guidelines, policies and more nuanced content are needed to develop culturally relevant and appropriate adaptation policies.

    • James D. Ford
    • Laura Cameron
    • Tristan Pearce
    Reviews
    Nature Climate Change
    Volume: 6, P: 349-353

  • Two competing theories suggest that Arctic communities are either highly vulnerable to climate change, or demonstrate significant adaptive capacity. A review of the research shows that the challenge of Arctic adaptation is formidable, but can be overcome.

    • James D. Ford
    • Graham McDowell
    • Tristan Pearce
    Reviews
    Nature Climate Change
    Volume: 5, P: 1046-1053