Nature Search

Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity

Drug resistance remains a major challenge in cancer treatment. Here, the authors identify Connexin43 as target that enhances BRAF/MEKi efficacy by interfering with DNA repair pathways, overcoming drug resistance. They develop an mRNA therapy that improves efficacy and sensitizes resistant cells.

Adrián Varela-Vázquez
Amanda Guitián-Caamaño
María D. Mayán
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Erratum: Gap junctions and cancer: communicating for 50 years

Trond Aasen
Marc Mesnil
Dale W. Laird
Amendments and Corrections02 Dec 2016
Nature Reviews Cancer

Volume: 17, P: 74
Gap junctions and cancer: communicating for 50 years

In this Timeline article, Aasenet al. look back over 50 years of research linking gap junctions and connexins to cancer, highlighting the conditional nature of their role in cancer progression, future challenges and therapeutic strategies.

Trond Aasen
Marc Mesnil
Dale W. Laird
Reviews21 Oct 2016
Nature Reviews Cancer

Volume: 16, P: 775-788
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

Aasen et al. boost the efficiency of human induced pluripotent stem (iPS) cell generation 100-fold by starting with keratinocytes rather than fibroblasts. They also produce iPS cells from plucked adult hair, an easily accessible source of cells that avoids the need for a biopsy.

Trond Aasen
Angel Raya
Juan Carlos Izpisúa Belmonte
Research17 Oct 2008
Nature Biotechnology

Volume: 26, P: 1276-1284
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

The generation of patient-specific induced pluripotent stem cells (iPS cells) is thought to hold great therapeutic potential. Here, somatic cells from Fanconi anaemia patients are reprogrammed to pluripotency after correction of the genetic defect, generating patient-specific iPS cells.

Ángel Raya
Ignasi Rodríguez-Pizà
Juan Carlos Izpisúa Belmonte
Research31 May 2009
Nature

Volume: 460, P: 53-59
Connexins in cancer: bridging the gap to the clinic

Trond Aasen
Edward Leithe
Arantxa Tabernero
ReviewsOpen Access27 Feb 2019
Oncogene

Volume: 38, P: 4429-4451
Lipid and DHA-production in Aurantiochytrium sp. – Responses to nitrogen starvation and oxygen limitation revealed by analyses of production kinetics and global transcriptomes

Tonje M. B. Heggeset
Helga Ertesvåg
Inga Marie Aasen
ResearchOpen Access19 Dec 2019
Scientific Reports

Volume: 9, P: 1-13
Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells

Trond Aasen
Juan Carlos Izpisúa Belmonte
Protocols04 Feb 2010
Nature Protocols

Volume: 5, P: 371-382
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Marta Varela-Eirín
Adrián Varela-Vázquez
María D. Mayán
ResearchOpen Access05 Dec 2018
Cell Death & Disease

Volume: 9, P: 1-16
The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression

Trond Aasen
Malcolm B Hodgins
Sheila V Graham
Research11 Sept 2003
Oncogene

Volume: 22, P: 7969-7980

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Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity

Erratum: Gap junctions and cancer: communicating for 50 years

Gap junctions and cancer: communicating for 50 years

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

Connexins in cancer: bridging the gap to the clinic

Lipid and DHA-production in Aurantiochytrium sp. – Responses to nitrogen starvation and oxygen limitation revealed by analyses of production kinetics and global transcriptomes

Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression

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