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Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer

The prostate cancer tumour microenvironment in the context of treatment remains to be explored. Here, single-cell RNA-sequencing and spatial transcriptomics analysis of samples at multiple treatment points from 120 patients suggests that club-like cells may contribute to treatment resistance.

Antti Kiviaho
Sini K. Eerola
Matti Nykter
ResearchOpen Access16 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Spatial transcriptomics reveals strong association between SFRP4 and extracellular matrix remodeling in prostate cancer

Leveraging spatial and bulk transcriptomics, DNA methylomics and proteomics on the same prostate cancer tissue samples, this study provides insights on the tissue origin and role of SFRP4 gene expression in aggressive prostate cancer.

Maria K. Andersen
Sebastian Krossa
May-Britt Tessem
ResearchOpen Access08 Nov 2024
Communications Biology

Volume: 7, P: 1-15
Utility of T₂-weighted MRI texture analysis in assessment of peripheral zone prostate cancer aggressiveness: a single-arm, multicenter study

Gabriel A. Nketiah
Mattijs Elschot
Heninrich von Busch
ResearchOpen Access22 Jan 2021
Scientific Reports

Volume: 11, P: 1-13

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