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Human skeletal muscle plasmalemma alters its structure to change its Ca²⁺-handling following heavy-load resistance exercise

Heavy-load eccentric exercise causes an increase in cytoplasmic Ca²⁺ that can damage muscles. Here the authors show that the t-tubule system remodels into vacuoles that can sequester calcium from the cytoplasm and are not responsive to store-operated Ca²⁺ entry, thereby potentially protecting muscles against elevated [Ca²⁺].

Tanya R. Cully
Robyn M. Murphy
Bradley S. Launikonis
ResearchOpen Access13 Feb 2017
Nature Communications

Volume: 8, P: 1-10
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus

Bone mineral density and lean skeletal mass are heritable traits. Here, Medina-Gomez and colleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children, and show genetic loci with pleiotropic effects on both traits.

Carolina Medina-Gomez
John P. Kemp
Fernando Rivadeneira
ResearchOpen Access25 Jul 2017
Nature Communications

Volume: 8, P: 1-11
Acute changes in antioxidants and oxidative stress to vigorous arm exercise: an intervention trial in persons with spinal cord injury and healthy controls

Matthijs F. Wouda
Hanne Bjørg Slettahjell
Emil Kostovski
ResearchOpen Access13 Jul 2023
Spinal Cord Series and Cases

Volume: 9, P: 1-8

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