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Modeling integration site data for safety assessment with MELISSA

Viral vector integration can affect the safety of gene and cell therapies. Here, authors introduce MELISSA, a regression-based statistical tool that quantifies integration site risks and clone growth effects, aiding the safety evaluation of therapies in both research and clinical settings.

Tsai-Yu Lin
Giacomo Ceoldo
Danilo Pellin
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Author Correction: SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

Guihua Wang
Jie Long
Hui-Kuan Lin
Amendments and Corrections29 Apr 2021
Nature Cell Biology

Volume: 23, P: 676
Functional defects in FOXG1 variants predict the severity of brain anomalies in FOXG1 syndrome

Tsai-Yu Lin
Lee-Chin Wong
Jin-Wu Tsai
ResearchOpen Access16 Jun 2025
Molecular Psychiatry

Volume: 30, P: 4824-4835
2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Many cellular and virus messenger RNAs are methylated at the 2′-O positions of the 5′ guanosine cap. The role of 2′-O methylation in virus infection has been unclear. These authors show that this form of methylation enables several unrelated viruses to evade the antiviral effects of genes stimulated by type I interferon.

Stephane Daffis
Kristy J. Szretter
Michael S. Diamond
Research17 Nov 2010
Nature

Volume: 468, P: 452-456
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

Wang et al. show that Akt methylation by SETDB1 is recognized by demethylase JMJD2A, which then recruits E3 ligases to induce K63-linked Akt ubiquitination, leading to Akt activation and tumorigenesis.

Guihua Wang
Jie Long
Hui-Kuan Lin
Research28 Jan 2019
Nature Cell Biology

Volume: 21, P: 214-225
Mixed-linker strategy for suppressing structural flexibility of metal-organic framework membranes for gas separation

Metal–organic frameworks have demonstrated great promise for gas separation membranes, but their structural flexibility hinders their stability and hence sieving performance. Here, the authors systematically tune the ratio of mixed linkers in CAU-10-based MOF membranes, finding the optimal ratio that suppresses structural flexibility and enhances CO₂/CH₄ separation performance.

Chung-Kai Chang
Ting-Rong Ko
Dun-Yen Kang
ResearchOpen Access10 Jun 2023
Communications Chemistry

Volume: 6, P: 1-12
Comparison of proximal versus distal upper-limb robotic rehabilitation on motor performance after stroke: a cluster controlled trial

Yu-wei Hsieh
Keh-chung Lin
Chia-ling Chen
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial

Ting-Yu Lin
Yueh-Fu Fang
Yu-Lun Lo
ResearchOpen Access17 Aug 2017
Scientific Reports

Volume: 7, P: 1-9

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Modeling integration site data for safety assessment with MELISSA

Author Correction: SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

Functional defects in FOXG1 variants predict the severity of brain anomalies in FOXG1 syndrome

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

Mixed-linker strategy for suppressing structural flexibility of metal-organic framework membranes for gas separation

Comparison of proximal versus distal upper-limb robotic rehabilitation on motor performance after stroke: a cluster controlled trial

Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial

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