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SARS-CoV-2 rebound and post-acute mortality and hospitalization among patients admitted with COVID-19: cohort study

SARS-CoV-2 rebound is a recurrence of symptoms or return to test positivity after initial recovery. Here, the authors demonstrate an association between SARS-CoV-2 rebound and post-acute COVID conditions using data from Hong Kong.

Ka Chun Chong
Yuchen Wei
Zihao Guo
ResearchOpen Access28 Jul 2025
Nature Communications

Volume: 16, P: 1-10
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.

Hin Chu
Bingjie Hu
Kwok-Yung Yuen
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-15
Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3

Here, the authors show that a single mutation in JN.1 spike, L455S, confers better spike cleavage and enhances virus infectivity in differentiated primary human nasal epithelial cells while increasing immune evasiveness, contributing to the efficient spread of JN.1.

Yuanchen Liu
Xiaoyu Zhao
Hin Chu
ResearchOpen Access09 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

The replication and pathogenicity of the Omicron variant of SARS-CoV-2 is attenuated compared with the original strain and other variants.

Huiping Shuai
Jasper Fuk-Woo Chan
Hin Chu
Research21 Jan 2022
Nature

Volume: 603, P: 693-699
Coronaviruses exploit a host cysteine-aspartic protease for replication

Coronaviruses exploit the host caspase-6 to cleave coronavirus nucleocapsid protein into fragments with interferon-antagonizing activity to facilitate virus replication.

Hin Chu
Yuxin Hou
Kwok-Yung Yuen
Research03 Aug 2022
Nature

Volume: 609, P: 785-792
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Although extrapulmonary complications of different organ systems are recognized in patients with severe COVID19 effects are less well studied. Here, Qiao et al. characterize the pathogenesis of SARS-CoV-2 on bone metabolism in Syrian hamster and find that bone loss is associated with virus-mediated cytokine dysregulation.

Wei Qiao
Hui En Lau
Kelvin Wai-Kwok Yeung
ResearchOpen Access09 May 2022
Nature Communications

Volume: 13, P: 1-16

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SARS-CoV-2 rebound and post-acute mortality and hospitalization among patients admitted with COVID-19: cohort study

Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

Coronaviruses exploit a host cysteine-aspartic protease for replication

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

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