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An interpretable data-driven prediction model to anticipate scoliosis in spinal muscular atrophy in the era of (gene-) therapies

Tu-Lan Vu-Han
Rodrigo Bermudez Schettino
Matthias Pumberger
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-11
BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage checkpoint signaling in oncogenic cells.

Fred C. Lam
Yi Wen Kong
Michael B. Yaffe
ResearchOpen Access14 Aug 2020
Nature Communications

Volume: 11, P: 1-20
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

The blood-brain barrier often limits effective delivery of treatments for glioblastoma . In this study, the authors develop transferrin-functionalized nanoparticles able to traverse the intact blood-brain barrier and deliver combination temozolomide and bromodomain inhibitor therapy to glioma-bearing mice.

Fred C. Lam
Stephen W. Morton
Paula T Hammond
ResearchOpen Access18 May 2018
Nature Communications

Volume: 9, P: 1-11

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