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Showing 1–6 of 6 results
Advanced filters: Author: Tudor Constantin Clear advanced filters

  • Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

    • Christopher Abbosh
    • Nicolai J. Birkbak
    • Charles Swanton
    Research
    Nature
    Volume: 545, P: 446-451

  • Age-related macular degeneration (AMD) is a leading cause of blindness and is characterised by the accumulation of lipid deposits, called drusen. Here, the authors show that mice lacking chloride intracellular channel 4 in retinal pigment epithelium have defective lipid processing in the eye and pathological features mirroring human AMD, including drusen formation.

    • Jen-Zen Chuang
    • Nan Yang
    • Ching-Hwa Sung
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Coordinated movement critically depends on sensory feedback from muscle spindles (MSs) and Golgi tendon organs (GTOs) but the afferents supplying this proprioceptive feedback have remained genetically inseparable. Here the authors use single cell transcriptome analysis to reveal the molecular basis of MS (groups Ia and II) and GTO (group Ib) afferent identities in the mouse.

    • Katherine M. Oliver
    • Danny M. Florez-Paz
    • Joriene C. de Nooij
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19