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Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8⁺ T cell immunity

Broadly neutralising anti-HIV-1 antibody (bNAb) administration in nonhuman primates has been shown to stimulate adaptive T cell-specific immunity, with infection prevention observed. In this work, the authors longitudinally analyse HIV-1 specific cellular immunity in HIV-1- infected individuals starting ART with or without adjunctive bNAb treatment.

Miriam Rosás-Umbert
Jesper D. Gunst
Ole S. Søgaard
ResearchOpen Access29 Oct 2022
Nature Communications

Volume: 13, P: 1-12
Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

Vaccines that elicit HIV-specific T-cell responses did not prevent viral rebound in people living with HIV upon antiretroviral treatment (ART) interruption, but associated with longer time off ART in some trial participants, suggesting their immunogenicity may benefit future cure approaches.

Lucia Bailón
Anuska Llano
Jordi Puig
Research27 Oct 2022
Nature Medicine

Volume: 28, P: 2611-2621
Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota

Alessandra Borgognone
Aleix Elizalde-Torrent
Roger Paredes
ResearchOpen Access30 Dec 2022
npj Biofilms and Microbiomes

Volume: 8, P: 1-9

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