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COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe COVID-19 infection.

Toni M. Delorey
Carly G. K. Ziegler
Aviv Regev
Research29 Apr 2021
Nature

Volume: 595, P: 107-113
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

Here, using clinical samples and autopsy tissues, the authors combine fast-colorimetric test (LAMP) for SARS-CoV-2 infection and large-scale shotgun metatranscriptomics for host, viral, and microbial profiling and provide a map of the viral genetic features of the New York City outbreak and associate specific host responses and gene expression perturbations with SARS-CoV-2 infection.

Daniel Butler
Christopher Mozsary
Christopher E. Mason
ResearchOpen Access12 Mar 2021
Nature Communications

Volume: 12, P: 1-17
PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

CAR T cells targeting PSMA and engineered to be resistant to immunosuppressive TGFβ signaling exhibit dose-dependent toxicity and expansion following infusion, with some transient antitumor activity, in patients with metastatic castration-resistant prostate cancer

Vivek Narayan
Julie S. Barber-Rotenberg
Naomi B. Haas
Research21 Mar 2022
Nature Medicine

Volume: 28, P: 724-734
The spatial landscape of lung pathology during COVID-19 progression

Imaging mass cytometry of the human lung reveals the cellular composition and spatial architecture during COVID-19 and other acute injuries, enabling the characterization of lung pathophysiology from structural, immunological and clinical perspectives.

André F. Rendeiro
Hiranmayi Ravichandran
Robert E. Schwartz
Research29 Mar 2021
Nature

Volume: 593, P: 564-569

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COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

The spatial landscape of lung pathology during COVID-19 progression

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