Begg et al. show that S100A8/9 expression is associated with risk of progression in early-stage triple-negative breast cancer cohorts. Using a small inhibitor screen, the authors identify PIM kinase inhibitors to target S100A8/A9 expression, improving antitumor response when combined with immune checkpoint blockade in mice.
- Lauren R. Begg
- Adrienne M. Orriols
- Dai Horiuchi
