Nature Search

Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

U. Benjamin Kaupp
Tetsuhiro Niidome
Shosaku Numa
Research14 Dec 1989
Nature

Volume: 342, P: 762-766
Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm

Ingo Weyand
Matthias Godde
U. Benjamin Kaupp
Research28 Apr 1994
Nature

Volume: 368, P: 859-863
The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods

The cryo-EM structure of the bovine rod CNG channel, isolated from retina, sheds light onto the structural basis for the subunit stoichiometry and reveals an additional gate within the ion conduction pathway contributed by the CNGB1 subunit.

Diane C. A. Barret
Gebhard F. X. Schertler
Jacopo Marino
Research30 Dec 2021
Nature Structural & Molecular Biology

Volume: 29, P: 32-39
Olfactory signalling in vertebrates and insects: differences and commonalities

Both vertebrates and insects use a broad repertoire of receptors to detect olfactory environmental cues. Kaupp reviews our current understanding of olfactory signalling, highlighting shared features and important differences between the systems used by vertebrates and insects.

U. Benjamin Kaupp
Reviews10 Feb 2010
Nature Reviews Neuroscience

Volume: 11, P: 188-200
Multifocal imaging for precise, label-free tracking of fast biological processes in 3D

Multifocal imaging suffers from a number of limitations. Here the authors report an open-source 3D reconstruction algorithm to enable label-free tracking of spherical and filamentous structures which they use to characterise fluid flow and flagellar beating of human and sea urchin sperm.

Jan N. Hansen
An Gong
Luis Alvarez
ResearchOpen Access28 Jul 2021
Nature Communications

Volume: 12, P: 1-15
Sperm navigation along helical paths in 3D chemoattractant landscapes

Sperm use external cues to find the egg using ill-defined principles. Here the authors use holographic microscopy and optochemical tools to study sperm swimming in light-sculpted chemical 3D landscapes; they show that sperm translate the temporal stimulation pattern into multiple swimming behaviours to orient deterministically in a gradient.

Jan F. Jikeli
Luis Alvarez
U. Benjamin Kaupp
ResearchOpen Access17 Aug 2015
Nature Communications

Volume: 6, P: 1-10
The signal flow and motor response controling chemotaxis of sea urchin sperm

U. Benjamin Kaupp
Johannes Solzin
Ingo Weyand
Research31 Jan 2003
Nature Cell Biology

Volume: 5, P: 109-117
Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors

Heinz G. Körschen
Michael Beyermann
U. Benjamin Kaupp
Research19 Aug 1999
Nature

Volume: 400, P: 761-766
The CatSper channel mediates progesterone-induced Ca²⁺ influx in human sperm

Progesterone stimulates an increase in Ca²⁺ levels in human sperm, but the underlying signalling mechanism is poorly understood. Two studies now show that progesterone activates the sperm-specific, pH-sensitive CatSper calcium channel, leading to a rapid influx of Ca²⁺ ions into the spermatozoa. These results should help to define the physiological role of progesterone and CatSper in sperm, and could lead to the development of new classes of non-hormonal contraceptives.

Timo Strünker
Normann Goodwin
U. Benjamin Kaupp
Research16 Mar 2011
Nature

Volume: 471, P: 382-386
Control of intracellular pH and bicarbonate by CO₂ diffusion into human sperm

Bicarbonate (HCO₃⁻) is critical in sperm for stimulation of cAMP synthesis during fertilization, though there is dispute over how HCO₃⁻ is transported into sperm. Here the authors use limit-of-detection LC/MS to characterize sperm protein expression and show that HCO₃⁻ is produced from CO₂ diffusion into sperm rather than active transport.

Elena Grahn
Svenja V. Kaufmann
U.Benjamin Kaupp
ResearchOpen Access05 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Fast manipulation of cellular cAMP level by light in vivo

Saskia Schröder-Lang
Martin Schwärzel
Georg Nagel
Research26 Nov 2006
Nature Methods

Volume: 4, P: 39-42
A K⁺-selective cGMP-gated ion channel controls chemosensation of sperm

Timo Strünker
Ingo Weyand
U.Benjamin Kaupp
Research10 Sept 2006
Nature Cell Biology

Volume: 8, P: 1149-1154
Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli

David R. Stevens
Reinhard Seifert
Bernd Lindemann
Research11 Oct 2001
Nature

Volume: 413, P: 631-635
Molecular identification of a hyperpolarization-activated channel in sea urchin sperm

Renate Gauss
Reinhard Seifert
U. Benjamin Kaupp
Research11 Jun 1998
Nature

Volume: 393, P: 583-587
Human sperm steer with second harmonics of the flagellar beat

The mechanism allowing sperm to steer is not fully understood. The authors find that superposition of two harmonic waves breaks the flagellar beat symmetry temporally rather than spatially, and that this mechanism is enhanced by the sexual hormone progesterone, which changes the motility pattern.

Guglielmo Saggiorato
Luis Alvarez
Jens Elgeti
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-9

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Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm

The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods

Olfactory signalling in vertebrates and insects: differences and commonalities

Multifocal imaging for precise, label-free tracking of fast biological processes in 3D

Sperm navigation along helical paths in 3D chemoattractant landscapes

The signal flow and motor response controling chemotaxis of sea urchin sperm

Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors

The CatSper channel mediates progesterone-induced Ca²⁺ influx in human sperm

Control of intracellular pH and bicarbonate by CO₂ diffusion into human sperm

Fast manipulation of cellular cAMP level by light in vivo

A K⁺-selective cGMP-gated ion channel controls chemosensation of sperm

Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli

Molecular identification of a hyperpolarization-activated channel in sea urchin sperm

Human sperm steer with second harmonics of the flagellar beat

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