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Showing 1–4 of 4 results
Advanced filters: Author: Ucheor B Choi Clear advanced filters

  • Khan et al. show that Sec18 uses both D1 and D2 AAA+ rings cooperatively, opening them laterally for SNARE substrate loading and for subsequent release of SNAREs.

    • Yousuf A. Khan
    • K. Ian White
    • Axel T. Brunger
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1708-1720

  • Single-molecule FRET studies have resulted in an experimentally derived model of a synaptotagmin–SNARE complex. In this complex of SNARE with synaptotagmin 1, the arrangement of the Ca2+-binding loops is similar to that of the structure of SNARE-induced Ca2+-bound synaptotagmin 3. This suggests a common molecular mechanism by which the synaptotagmin–SNARE interaction plays a role in Ca2+-triggered vesicle fusion.

    • Ucheor B Choi
    • Pavel Strop
    • Keith R Weninger
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 318-324

  • The first crystal structures of complexes between synaptotagmin-1 and neuronal SNARE, bound to either Ca2+ or Mg2+, are described, and show that Ca2+-triggered neurotransmitter release relies on a large, Ca2+-independent interface.

    • Qiangjun Zhou
    • Ying Lai
    • Axel T. Brunger
    Research
    Nature
    Volume: 525, P: 62-67