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Anoctamin 1/TMEM16A controls intestinal Cl⁻ secretion induced by carbachol and cholera toxin

Byeongjun Lee
Gyu-Sang Hong
Uhtaek Oh
ResearchOpen Access05 Aug 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-14
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

This study reports that the Ca²⁺-activated chloride channel anoctamin 1 (ANO1) is activated by heat and is expressed in mouse dorsal root ganglion neurons. Ano1 deletion leads to a deficit in thermal nociception, suggesting that this channel acts as a new heat sensor in pain pathways.

Hawon Cho
Young Duk Yang
Uhtaek Oh
Research27 May 2012
Nature Neuroscience

Volume: 15, P: 1015-1021
TMEM16A confers receptor-activated calcium-dependent chloride conductance

Young Duk Yang
Hawon Cho
Uhtaek Oh
Research24 Aug 2008
Nature

Volume: 455, P: 1210-1215