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Showing 1–7 of 7 results
Advanced filters: Author: Ulf Martens Clear advanced filters

  • Many patients with breast cancer develop resistance to the drug tamoxifen and relapse. Here Johansson et al. identify the nuclear receptor retinoic acid receptor alpha (RARA) as a marker of tamoxifen resistance and show that RARA expression correlates negatively with relapse-free survival of patients.

    • Henrik J. Johansson
    • Betzabe C. Sanchez
    • Janne Lehtiö
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • In order to find a general treatment for cancer, this study found that MTH1 activity is essential for the survival of transformed cells, and isolated two small-molecule inhibitors of MTH1, TH287 and TH588 — in the presence of these inhibitors, damaged nucleotides are incorporated into DNA only in cancer cells, causing cytotoxicity and eliciting a beneficial response in patient-derived mouse xenograft models.

    • Helge Gad
    • Tobias Koolmeister
    • Thomas Helleday
    Research
    Nature
    Volume: 508, P: 215-221

  • The NUDIX hydrolases are known to be involved in several cellular processes and diseases, such as cancer, but remain poorly characterized as a family. Here, the authors provide a comprehensive analysis of the structural, biochemical, and expression properties of 18 human NUDIX proteins, and begin to address their functional inter-relationships.

    • Jordi Carreras-Puigvert
    • Marinka Zitnik
    • Thomas Helleday
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • The magnetic properties of a ferromagnetic layer stack are controlled on attosecond timescales through optically induced spin and orbital momentum transfer, demonstrating a coherent regime of ultrafast magnetism.

    • Florian Siegrist
    • Julia A. Gessner
    • Martin Schultze
    Research
    Nature
    Volume: 571, P: 240-244

  • In Himalayan songbirds, the speciation rate is ultimately set by ecological competition, rather than by the rate of acquisition of reproductive isolation.

    • Trevor D. Price
    • Daniel M. Hooper
    • Dhananjai Mohan
    Research
    Nature
    Volume: 509, P: 222-225