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Showing 1–3 of 3 results
Advanced filters: Author: Ulf Schönermarck Clear advanced filters

  • Available evidence suggests that rituximab may be safe and effective for the treatment of refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Two studies now show that rituximab is not less effective than cyclophosphamide for treating ANCA-associated vasculitides. Should rituximab be the new standard of care for patients with ANCA-associated vasculitis?

    • Ulf Schönermarck
    • Kirsten de Groot
    News & Views
    Nature Reviews Nephrology
    Volume: 7, P: 6-8

  • Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides are characterized by inflammation of blood vessels, which can lead to severe organ and tissue damage. Previously considered life-threatening, they are now treated using remission induction and maintenance therapies. This article outlines the current treatment regimens, reviews clinical trial data, and discusses new developments in the treatment of ANCA-associated vasculitides.

    • Ulf Schönermarck
    • Wolfgang L. Gross
    • Kirsten de Groot
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 25-36

  • Neutrophils release neutrophil extracellular traps (NETs), chromatin fibers that can ensnare bacteria. In small-vessel vasculitis (SVV), a chronic inflammatory condition linked to antineutrophil autoantibodies, these NETs express SVV-associated autoantigens, accumulate in inflamed kidneys and promote the autoimmune response against neutrophils in people with SVV.

    • Kai Kessenbrock
    • Markus Krumbholz
    • Dieter E Jenne
    Research
    Nature Medicine
    Volume: 15, P: 623-625