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Showing 1–4 of 4 results
Advanced filters: Author: Ulrik Lindforss Clear advanced filters

  • Natural killer (NK) cells control tumor growth through direct cytotoxicity and recruitment of other leukocytes. Here, using photoconversion-based labeling to track the fate of NK cells in vivo, the authors demonstrate that loss of NK cell function occurs very rapidly following their entry into tumors, but can be reversed by IL-15 administration.

    • Isaac Dean
    • Colin Y. C. Lee
    • David R. Withers
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Stromal cells are key players in immune cell homeostasis. Here, the authors decipher subset-specific human stromal responses in inflammatory bowel disease and suggest that intestinal PDGFRA+CD142−/low fibroblasts guide monocyte transition to macrophages in human gut through GM-CSF.

    • Egle Kvedaraite
    • Magda Lourda
    • Mattias Svensson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Murine ILCs can modulate T cell responses in MHCII-dependent manner. Here the authors show that human ILCs process and present antigens and induce T-cell responses upon exposure to IL-1-family cytokines; along with the article by Lehmann et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.

    • Anna Rao
    • Otto Strauss
    • Jenny Mjösberg
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

    • Malcolm G Dunlop
    • Sara E Dobbins
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 44, P: 770-776