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Showing 1–3 of 3 results
Advanced filters: Author: Ursula E. Schoeberl Clear advanced filters

  • Here the authors identify PHF3 SPOC domain as a reader of the phosphorylated RNA polymerase II (Pol II) C-terminal domain. They show that PHF3 clusters with Pol II complexes in cells, drives phase separation of Pol II in vitro, and regulates neuronal gene expression and neuronal differentiation.

    • Lisa-Marie Appel
    • Vedran Franke
    • Dea Slade
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-24

  • Here the authors show that in activated B cells, RIF1 primarily binds early-replicating active chromatin and promotes early replication. RIF1 and MCM proteins establish early replication timing signatures genome-wide and ensure early replication of highly transcribed genes.

    • Daniel Malzl
    • Mihaela Peycheva
    • Rushad Pavri
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18