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Showing 1–5 of 5 results
Advanced filters: Author: Usheer Kanjee Clear advanced filters

  • Although the precise function of Tryptophan rich antigen multi-gene family (TRAgs) proteins is not known in any Plasmodium species several members of the P. vivax TRAg family have been reported to have red blood cell binding properties. Here, Kundu and Naskar et al. provide the X-ray crystallography structure of a P. vivax TRAg domain of PVP01_0000100. Structural and biochemical assays suggest a lipid binding function for a pan-Plasmodium multi-gene family.

    • Prasun Kundu
    • Deboki Naskar
    • Julian C. Rayner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • During Plasmodium intra-erythrocytic developmental, parasites compromise the structural integrity of host red-blood cells. Here, Clark et al. develop a flow cytometric osmotic stability assay to show that P. vivax infection destabilizes host reticulocytes, which are less stable than P. falciparum-infected normocytes.

    • Martha A. Clark
    • Usheer Kanjee
    • Manoj T. Duraisingh
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • A subnanometre-resolution cryo-electron microscopy structure of the Rh5–CyRPA–Ripr complex of Plasmodium falciparum provides insights into how this ligand interacts with the receptor basigin in erythrocyte hosts.

    • Wilson Wong
    • Rick Huang
    • Alan F. Cowman
    Research
    Nature
    Volume: 565, P: 118-121

  • Benjamin Ravenhill et al. use a mass spectrometry approach to enrich and quantify the proteome of the surface of red blood cells (RBCs) from donors in Senegal and the United Kingdom. They find 240 high confidence RBC cell surface proteins and identify differences between the populations as well as potential receptors for Plasmodium.

    • Benjamin J. Ravenhill
    • Usheer Kanjee
    • Michael P. Weekes
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-9

  • Elizabeth Egan and colleagues demonstrate that host ATP binding cassette transporter ABCB6, which encodes the Langereis blood group antigen, promotes erythrocyte invasion by the malaria parasite Plasmodium falciparum. This study suggests that asymptomatic Langereis null individuals may be better protected from malaria.

    • Elizabeth S. Egan
    • Michael P. Weekes
    • Manoj T. Duraisingh
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-9